The good news is that USA Today has broken an exclusive story about the next game in the Ghostbusters franchise (also good news is that there is even going to be a 'next game' in the franchise)
Iffy news is that it's going to be an isometric (lot of that going around lately) action/shooter instead of the third-person romp we got last year and that it's going to be a downloadable game. Though I should say it looks pretty enough.
Bad news is that none of the movie's stars (or characters?) are involved.
Now that that's out of the way, the game picks up after the first 2009's game and stars it's 'rookie' character. Now there's nothing in the USA Today piece about this but if I were guessing I'd say that the story is probably centered on a new 'Busters franchise owned by said rookie.
You'd have to have beaten the fist game to understand why I think that - I'm not going to explain it here. I try to keep the spoilers to a minimum.